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An invasive approach includes delivery of medication directly to the brain through injection/surgical implants or disruption of the tight endothelial junction of the BBB to facilitate drug penetration

Additionally, nutritional status and body composition appear as additional determinants of IGF-1 levels

Unlike most peptides sold in research networks, GHK-Cu has been integrated for 40 years in premium cosmeceutical formulations (Procyte Corporation, NeoCutis, Estee Lauder Advanced Night Repair) after showing reproducible structural effects on human skin

doi: 10.1186/s13048-023-01319-7 30 SheidaADavarRTabibnejadNEftekharM